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Diet Plan For Cholesterol

A high level of cholesterol has been linked with a variety of diseases. A high level of cholesterol in the body can be brought about by a number of things. On of them is by following a diet that is high in saturated fat and LDL or “bad” cholesterol which is the type of diet that most people seem to keep nowadays.

Prolonged regular inactivity or lack of proper exercise smoking and drinking habits can also contribute to the unhealthy increase of bad cholesterol levels that may lead to heart disease in the long term. Heart disease is known to be the number one killer in the US. It is important for people to realize that lowering their cholesterol levels can help reduce the risks of heart disease and stroke. This can be done in a variety of ways.

A healthy lifestyle can help a lot in trying to reduce high cholesterol levels and therefore reduce the risk of developing heart disease. The earlier an individual starts such a practice the less likely he or she will be suffering from the effects of heart disease with age.

Following a healthy lifestyle will include taking part in a regular exercise routine as well as eating a low cholesterol diet. A healthy diet is very important for an individual trying to reduce facing the risks of having high cholesterol levels.

If you are trying to formulate a low cholesterol diet plan you should be able to have a clear idea of what you will be doing and what it will take. Knowing and understanding your objectives of following a low cholesterol diet will make you more likely adhere to it more sincerely and in the long term and not just as a fad diet that can come and go. Before you begin indulging in any strict diet like a low cholesterol diet program you should have some idea on why some foods are safe for you to eat and why some are not.

The basic idea behind every low cholesterol diet plan is to try to decrease the total intake of saturated fat calories and cholesterol in the body not only to reduce cholesterol and fat levels but also to lose some weight. The different types of foods that will be able to do this for you include mainly fruits and vegetables.

Foods belonging in this group have very high fiber content. Dietary fiber soaks cholesterol like sponge and helps get rid of it by disposing it out of the body. Fruits such as apples oranges and pears are high in fiber content. This also includes oats and carrots that you can add to your diet.

About the writer:nbsp;nbsp;1000s of Affordable HealthMedicalFitness and Beauty Products hereTradePlanets.comEarlyPlanet.comWorldHealthPages.comandWorldFitnessPages.com

Diabetic Disorders And Complications

Diabetes is a disease that if left untreated will lead to a wide range of complications involving a variety of bodily organs and systems. These complications are all very serious and can be crippling or deadly. For the diabetic the best way to prevent or minimize any disorder arising from their disease is through proper management of their disease. This is accomplished through lifestyle changes involving diet exercise medication and regular visits to the doctor.

The primary cause for many of these complications revolves around high blood glucose sugar levels and the damage that it causes.

1. Diabetic Retinopathy This condition involves the retina of the eye. The capillaries of the retina undergo changes that lead to decreased blood flow known as ischemia. This leads to the presence of exudates or fluid in the eye “cotton wool” patches on the retina and a build up of fibrous tissue. This will result in vision impairment and even blindness if the diabetes is not properly managed. There is also an increased risk of cataracts due to high levels of glucose in the lens of the eye.

2. Diabetic Ketoacidosis This is primarily a condition that is specific to type 1 diabetes. It occurs when there is an insulin deficit and glucose can not enter the cells to be used for energy. The body responds by metabolizing fat and protein which causes blood pH to drop and the dropping of ketone bodies into the urine. This affects respirations which can have a fruity smell disrupts heart function depresses the central nervous system drops blood pressure and a number of other symptoms which can lead to coma and death.

3. Diabetic Neuropathy Neuropathy is a deterioration or loss of nerve function. It is caused primarily by a thickening of the blood vessels that supply the nerves with nutrients. The symptoms first start in the toes and feet and work their way up to the rest of the body.

4. Diabetic Nephropathy A disorder of the kidneys diabetic nephropathy affects about 20 to 40 percent of all diabetics. Although the exact cause is unknown it is believed that high glucose causes damage glomerulosclerosis which affects the filtering function of the kidneys. This disease is usually accompanied by high blood pressure which needs to be aggressively treated.

5. Diabetic Hypoglycemia Also known as low blood sugar this condition is common in those who have type 1 diabetes. It will occur in type 2 diabetics who are taking oral hypoglycemic medications. The symptoms which include dizziness lightheadedness loss of consciousness and in severe cases coma and death are a result of a lack of glucose needed for proper brain function.

6. Diabetic Cardiovascular Disease Diabetes causes a variety of changes to the cardiovascular system of it sufferers including atherosclerosis structural defects in the blood vessels and thickening of capillary basement membranes. All of this can lead an increased risk of coronary artery disease high blood pressure stroke and peripheral vascular disease.

Diabetes is a disease that affects all ages and types of people. Its effects can be devastating if not treated in a timely and appropriate manner. Left untreated it can cause serious health problems and even death. Everyone needs to be aware of this diseases and how some simple lifestyle changes can make the difference in the lives who suffer from diabetes.

About the writer:  To learn more about these complications and disorders of diabetes please visit the web site Diabetic Diet Plans by Clicking Here.

Diabetes-weight Control How Important Is It?

One diabetic is very sensitive to diabetesweight control link. It’s true that everybody should care about weight control. But this topic is extremely more important to diabetics.

Actually there is a ‘confusion’ regarding weight control. In fact diabetics face weight loss and gain problems. And they are asking why and how is this possible. This is true for both type 1 and 2 diabetics.

So if you have type1 diabetes at the beginning when you first are diagnosed with diabetes you may face a sudden weight loss. After beginning to take insulin as treatment of choice in your case you begin to gain weight. And you are wondering why.

At first your body tries to eliminate the excessive sugar through urine together with the calories it may need. That is why you face a sudden weight loss.

But after taking insulin you start to face weight gain problems because insulin delights to store fats in your body. On the other hand due to ‘craving syndrome’ you begin to have snacks to avoid hypoglycemia. But this leads to weight gain too.

Meanwhile type 2 diabetics most of the time are facing weight gain problems. And this is due to a bad diabetes management. Maybe at the beginning they may suddenly lose weight due to the same factors as for type 1 diabetics. There are many contradictory theories on this theme.

The most important thing is that type 2 diabetics are suffering from obesity. And this is their first great enemy to be eliminated. But this is not the only one. Together with other ‘bad’ lifestyle habits it contributes to worsen diabetes symptoms.

Now as a diabetic you should keep your diabetes under control considering even diabetesweight control link. This not only helps you to keep blood sugar levels at normal range but keeps you away from many other disorders you may face such as heart disease stroke or even death.

Also all the treatments you are taking to manage diabetes can face ‘zero’ resistance and can work better to lower your blood sugar levels.

About the writer:  for more info visit http://www.allaboutbeatingdiabetes.com/diabetesandweightgain.html

Diabetes Type – Natural Cure

The first type of diabetes is type 2 diabetes that affects the people who have high blood pressure are being overweight or have a family history of diabetes. Other causes may be the inactiveness strokes vascular disease or very high cholesterol levels. People over fortyfive are at risk for type 2 diabetes here as well. People who have type 2 diabetes but do not take insulin because the body produces enough insulin however the body does not recognize here the insulin as insulin and does not use it the right way. As a result then the glucose enters the blood stream and builds up causing the body to malfunction.The build up of glucose in the blood stream can cause the dehydration diabetic coma nerve damage hardening of the arteries and also kidney damage. The longer the body goes without a proper treatment more damage is done to the body and can then lead to death. Although type 2 diabetes is found in the more adults children are prone to this type of diabetes here as well.Type 1 diabetes typically shows up in children but can affect some adults as well . Type 1 diabetes is caused when the pancreas does not make any insulin that for the body. The insulin is needed so that the glucose can enter the body cells right instead of staying in the blood stream which leads to a build up of sugar in just the blood. If a build up of sugar in the blood occurs then longterm health problems will arise such as diabetic ketoacidosis which can also lead to death. If left untreated type 1 diabetes can often lead to kidney failure nerve damage blindness and some other eye problems as well as heart problems.Type 1 diabetes was called the juvenile diabetes for years before being given the current title. Type 1 diabetes was known to affect the children more so than it did adults. The different between type 1 and type 2 diabetes is also that with type 1 diabetes the body does not make insulin and with type 2 the body does not produce enough insulin make to sustain the body. For the most part most people who have type 2 diabetes just need a proper diet with exercise and some medication to treat the diabetes. With those type 1 diabetes most people have to take insulin shots and watch there sugar counts.Some symptoms of type 1 diabetes might be an wide increase in thirst hunger just after eating dry mouth and increased urination weight loss and fatigue. Type 2 diabetes may have the similar symptoms as type 1 diabetes but however most of the time you do not experience any symptoms. Some other symptoms you may get you notice with type 2 diabetes are tingling of the feet or hands weight gain itchy skin around the groin or the vaginal area as well as yeast infections and sores that heal slowly.If you experience here any of these symptoms you should seek a medical advice to confirm if it is or is not a form of diabetes. Early diagnosis and treatment is very significant for people who have diabetes or show any particular signs of diabetes symptoms. If you discover your diabetes much early you can work to counter it so before it becomes too serious. Prolonging a check up can cause more grown harm to the body.

About the writer:  Herbal Diabetes Treatment and Natural Cure Diabetes

Diabetes Treatment Plan To Help You Live A Prosperous Life

The consequences of Diabetes can be deadly unless you educate yourself about the disease and learn what changes you must make in order to keep yourself as healthy as possible. You and your physician need to develop a Diabetes treatment plan that includes eating a healthy diet starting a fitness program reducing your stress level and taking medication if necessary. Following a good plan will enable you to enjoy and sustain a long productive life.

The Two Main Types of Diabetes

Type 1 InsulinDependent Diabetes normally strikes children and young adults. Type 1 Diabetics do not produce insulin due partially to metabolism dysfunctions. Serious complications can occur with this disorder such as heart disease eye disorders and stroke but the chances of them developing are greatly reduced by making a few lifestyle changes.

Type 2 NonInsulinDependent Diabetes generally affects adults over 30 years of age. Type 2 Diabetes occurs when an insufficient amount of insulin is produced by the body.
Learning to live a healthier life and making some important changes will greatly improve the life of someone with Type 2 Diabetes. Although it takes hard work to make all necessary changes eating well staying fit and reducing stress they are well worth the effort in the long run. Complications associated with this type of Diabetes include kidney disorders heart disease circulatory problems and stroke.

Exercise for health

One vital part of a successful Diabetes treatment plan is exercise. It benefits diabetics by enabling them to lose weight and by normalizing their metabolism both of which will cause the body processes to become more adept at handling insulin. Mild forms of exercise should be implemented first to give the body a chance to adapt to increased activity gradually. Some very good activities for diabetics include swimming and walking. Water aerobics are great because they provide aerobic activity while allowing the body to remain cool at the same time.

Eating Healthy

Another important aspect of a good plan is consuming a healthy diet. Learning which foods to eat and which to avoid is of great importance to a diabetics future wellbeing. Not only will you lose weight and feel better you will also be better able to process insulin more efficiently. Consulting a dietician may be necessary to understand just how important a wellchosen food plan can be to a diabetic.

Eating several small meals a day as opposed to eating three large ones can help level out insulin so that it will remain stable throughout the day. This helps you avoid the extreme highs and lows often associated with blood sugar levels.

Medication

Taking your medication exactly as prescribed by the doctor is imperative and you should never skip dosages nor should you take medication earlier or later than scheduled. Testing your blood sugar levels should also be done precisely as directed.
Once you become accustomed to the diabetic treatment plan developed by you and your doctor you will feel like a new person because you will be healthier slimmer and much more physically fit. The most positive result of the new you will be your decreased risk of developing major complications and diseases enabling you to live a fantastic life.

Naturally treat diabetes with proven remedies. When medication doesnt work or taking to long to show results then the next best alternative is natural supplements which can curb diabetes and help your situation. Learn about the best natural remedies available and those that actually work go here.

About the writer:  Michael David is a content producer with years of experience.

Diabetes The 6 Points That Will Explain It For You

Diabetes mellitus is a chronic disease in which patients present with absolute or relative insulin deficiency. It effects about 6 of western populations and is a major contributing factor for heart attacks strokes kidney failure and peripheral vascular disease. Diabetes mellitus is also the leading cause of new blindness.

1. Types of Diabetes
There are four forms of the disease classified as: types 1 and 2 gestational and other specific types.

a.Type 1 Diabetes
In people with type 1 diabetes the pancreas is not producing insulin so blood glucose levels are higher than normal. People with this form of diabetes require daily insulin therapy to survive. This form is further split into idiopathic diabetes and immune mediated diabetes.

Type 1 accounts for around 10 to 15 of all people with diabetes. It is one of the most serious and common chronic diseases of childhood with about half of the people with this form of diabetes developing the disease before age 18. It is also known as insulin dependent diabetes mellitus IDDM or juvenileonset diabetes.

b. Type 2 Diabetes
Type 2 diabetes is marked by reduced levels of insulin insulin deficiency and/or the inability of the body to use insulin properly insulin resistance. This form of the disease is most common among people aged 40 years and over and accounts for 85 to 90 of all people with diabetes. Most people with type 2 diabetes are obese.

c. Gestational Diabetes
Gestational diabetes occurs during pregnancy in about 3 to 8 of females not previously diagnosed with diabetes. It is a temporary form of diabetes and usually disappears after the baby is born. However it is a marker of much greater risk of developing Type 2 diabetes later in life. Screening tests for gestational diabetes are usually performed around the 24th28th week of pregnancy.

d. Other Specific Diabetes Types
This includes people who have diabetes as a result of a genetic defect or exposure to certain drugs or chemicals.

2. Causes of Diabetes Mellitus
Diabetes is caused by resistance to or deficient production of the hormone insulin which helps glucose move from the blood into the cells.

In type 1 immune mediated diabetes pancreatic beta cell destruction results in failure to release insulin and ineffective transport of glucose. There is no known cause for idiopathic diabetes.

In type 2 diabetes the beta cells release insulin but receptors are insulin resistant and glucose transport is variable and inefficient. Some people may have conditions that can cause diabetes such as Cushing’s syndrome pancreatitis or liver disease.

Risk factors for type 2 diabetes include;

a.Obesity
b.History of Gestational diabetes
c.Lack of physical activity
d.Hypertension
e.Age 45
f.Ethnic groupings other than anglosaxon
g.Low HDL cholesterol levels
h.Impaired glucose tolerance
i.Family history

3. Signs and Symptoms of Diabetes
Symptoms of diabetes include; dehydration unexplained weight loss excessive thirst frequent need to urinate fatigue lethargy severe irritation and itching excessive hunger blurred vision skin and urinary infections and vaginitis.

4. Diagnosis
Diabetes or impaired glucose tolerance may be detected on routine blood tests as part of a general health check up or investigation for other symptoms or diseases. Diabetes tests check blood glucose levels.

Fasting blood glucose levels are classified as:
Normal: less than 100 mg/dl
Prediabetes: 100 to 125 mg/dl
Diabetes: greater than 125mg/dl

Because symptoms can be mild diabetes is often detected when a person suffers a problem that is caused by diabetes such as a heart attack stroke neuropathy poor wound healing or a foot ulcer certain eye problems certain fungal infections or delivering a baby with macrosomia or hypoglycemia.

5. Diabetes Treatment
Effective treatment endeavors to normalize blood glucose and reduce complications using insulin replacement diet and exercise. For those with very mild diabetes diet plus weight loss plus exercise may be enough to keep blood glucose within reasonable levels.

Dietary changes should focus on the ideas of weight loss and blood sugar regulation by keeping the blood sugar levels relatively stable throughout the day avoiding big peaks or troughs.

The principal treatment of type 1 diabetes even from its earliest stages is replacement of insulin combined with careful monitoring of blood glucose levels using blood testing monitors.

Type 2 diabetes may require oral antidiabetic drugs to stimulate body insulin production and increase insulin sensitivity. Various forms of natural supplements for diabetes treatment have also been postulated as effective.

People with unstable diabetes or those requiring many injections a day may benefit from an insulin pump which is worn on the body and delivers a continuous infusion of insulin via a needle implanted into the body.

Gestational diabetes is fully treatable but requires careful medical supervision throughout the pregnancy. Even though it may be transient untreated gestational diabetes can damage the health of the fetus or the mother.

Treatment for all forms of diabetes need not significantly impair normal activities if sufficient patient training awareness appropriate care discipline in testing and dosing of insulin is taken

6. Complications
Diabetes mellitus is the most common cause of adult kidney failure worldwide in the developed world. If undetected or poorly controlled diabetes can lead to blindness kidney failure lower limb amputation heart attack stroke and impotence.

About the writer:  Dick Aronson has a background of over 35 years in various facets of the Healthcare industry. He set up and ran clinical trials in more than 20 countries and he has also founded a number of small private health related businesses. Dick now runs a number of informative health websites Go” target=”_blank”>www.healthinnovationsonline.com/”>Go to Health Innovations Online and he has a herbal health store at Visit the Herbal Health Store

Diabetes Prevention Know How To Prevent Diabetes

Diabetes is a disease that results from too much sugar. Once it is there you can no longer control it. Least you can do is preventing it from happening. Keep your body fat percentage at a low level. Those who are obese are the ones at risk in getting diabetes. Eat small portons during meals and control where you get your sugar.

There are 800000 new diabetes cases diagnosed annually in the United States and this number is expected to rise. Diabetes is a chronic disease that claims many lives each year. It is the number six killer in the USA today. While there is no cure medical professionals are always looking for newer and more effective treatments.

Diabetes is different then other diseases. You either have cancer or you dont. You either have HIV or you dont. There is no in between. Its not really the case with diabetes. It is possible to be more diabetic than someone else. If your Fasting blood sugar is above a certain point you have diabetes. If it is further above you still have diabetes but your condition is much more severe.

Theres absolutely no doubt that dietary changes and weight loss can have a major impact on diabetes treatment. If you just lose 10 pounds for example you may be able to decrease your insulin resistance. Thats a significant breakthrough because insulin ushers blood sugar or glucose into your cells. In order for your cells to get the lifegiving energy they need they must accept rather than resist insulin.

While the symptoms of diabetes are not life threatening diabetes can lead to other more serious diseases and illnesses. People who have been diagnosed with diabetes are at a higher risk of diseases and illnesses such as heart disease stroke kidney disease neuropathy and nerve damage foot conditions and blindness. It is extremely important to control your diabetes in order to avoid the onset of these more serious and sometimes lifethreatening illnesses.

There are many changes people will have to make in order to live a healthy life. Though this may be difficult at first the rewards later on will be plenty. Living a healthy lifestyle will make a person happier in their life give them more energy during the day and will prepare the body for illness and other complications down the road. No one likes to think about aging but being prepared allows a person to live a full life.

First and foremost you should control your weight. Excess weight is the single highest cause of type 2 diabetes. So take a look at your diet and make sure the foods you are eating are providing you with all the essential nutrient minerals vitamins etc. that you need so that your body does not feel like it is being starved and store excess fat. A great way to get all of the important nutrients you need is to eat a diet high in raw fruits and vegetables or to supplement the gaps in your diet with products that contain all of the necessary vitamins and minerals your body needs to function properly.

About the writer:  Read about Natural Remedies. Also read about Cure for Diabetes and Natural Treatment for Diabetes

Diabetes Prevention Diet – Tips For Healthy Food Choices

In the United States millions of people are living with prediabetes or diabetes and dont even know it. Prediabetic individuals have too much sugar in the blood but not enough to be classified as a diabetic. The diabetes prevention diet has the ability to reverse and prevent the progression of diabetes as it promotes a relatively stable blood sugar.

Making bad dietary choices must be avoided simply because food is the main source of energy for the body. Therefore gaining a clear understanding of nutrition and dietary prevention strategies is essential.

Arbitrarily the most relevant goal of treating diabetes is to control blood sugar levels. More so it is imperative that the blood sugar remains at acceptable ranges to avoid hyperglycemia high or hypoglycemia low.

Prediabetics can prevent the development the type 2 diabetes if precautions are implemented and symptoms treated properly. More so the individual must make lifestyle changes and increasing the level of physical activity. A good nutritional plan to include natural diet and supplements are safe effective and non toxic.

The American Diabetes Association provides information that identifies the risk of prediabetes and what is necessary to stop the progression of diabetes all together. Making healthy food choices promotes a diabetes prevention diet that reduces the risk for further complications such as heart attack or stroke.

Having prediabetes gives you the opportunity to lose weight and reverse high blood sugar levels. A diabetes diet consists of a variety of healthy foods that are goaleffective.

Vegetables and Fruits: be sure that they are non starchy veggies such as spinach carrots broccoli or green beans

Whole Grain Foods: such as brown rice or whole wheat spaghetti

Dried Beans: such as kidney or pinto beans lentils

Fish: 2 3 times weekly

Lean Meats: such as cuts of beef or pork that end in loin pork loin or sirloin and remove skin from chicken and turkey

Nonfat Dairy: such as skim milk non fat yogurt and non fat cheese

Liquid Oils: for cooking instead of solid fats foods high in saturated or trans fat which is high in calories

Low Calories: cut back on high calorie snack foods such as chips cookies cakes or full fat ice cream

Choose Water: or calorie free diet drinks instead of high calorie drinks

Along with your diabetes prevention diet include physical activity in your daily routine. Nutrition diet and exercise go hand in hand to prevent and reverse the effects of pre diabetes.

A national awareness campaign was designed by the National Diabetes Education Program to target individuals at risk for type2 diabetes. This campaign identifies specific lifestyle changes that are guaranteed to normalize blood sugar levels.

About the writer:  Alvin Hopkinson is a leading health researcher in the area of natural remedies and diabetes natural treatment. Discover how you can reverse your diabetes for good using proven and effective home remedies. Visit his site for more useful articles such as: Type 2 Diabetes Medication Knowing How Each Medication Works

Diabetes – Natural Remedies For Heart Healthy Living

Diabetics without a proper diet plan to control the glucose building up in their blood stream is the prime target for heart complications and stroke because improper diets not only cause the fluctuation of glucose but also increases a diabetic’s blood pressure and cholesterol levels. Be sure to check with your dietitian or nutritionist to find a suitable healthy meal plan so you can keep your blood sugar in the healthy range without the risk of heart disease.

Here are some natural remedies for heart healthy living:
1. Cinnamon:
Cinnamon contains chemicals that tell the cells in your pancreas to release more insulin into the bloodstream.

2.Milk thistle:
Milk thistle contains sylimarin that can inhibit kidney damage related to diabetes.

3. Bilberry
Bilberry contains biotin that can reduce blood glucose levels.

4.Blueberry
Blueberry leaves are known to promote insulin production.

5. Dandelion root
Dandelion cleanses the liver and blood that indirectly helps treat diabetes.

6. Garlic and ginger
Beside having antitoxidant effects garlic and ginger also contribute to lowering cholesterol improve blood circulation in your body and preventing blood clots if taken with vitamin E.

7. Cayenne
Cayenne contains capsacin that can help to lower blood pressure and cholesterol levels as well as preventing heart attacks and strokes.

8. Ginkgo biloba aids small blood vessel circulation.

9. Bugle weed helps alleviate palpitation.

10. Wild yam enhances the body’s production of DHEA a hormone needed to prevent the onset of heart disease.

There are a lot of natural remedies can help to lower glucose in your bloodstream blood pressure and cholesterol levels as well as protecting you from heart attacks and strokes. For more information please visit: diabeteshealthyliving.blogspot.com/

Kyle J. Norton

About the writer:nbsp;nbsp;Kyle J. Norton
http://diabeteseatingplan.blogspot.com/
http://diabeteshealthyliving.blogspot.com/
I have been studying natural remedies for disease prevention for over 20 years and working as a financial consultant since 1990.

Diabetes Metabolic Syndrome And Cardiovascular Disease
There has been a dramatic increase in the incidence of diabetes worldwide which has been exacerbated by the growing obesity problem across the globe. Once thought of as primarily a childhood diseasesometimes referred to as juvenile diabetes now mostly Type 1 diabetesthe obesity crisis linked to the adoption of a highfat highcarbohydrate highcalorie American diet has resulted in skyrocketing rates of diabetes among adults across the world. To compound the global diabetes epidemic health professionals are witnessing an alarming increase in inflammatory diseases resulting from adult onset i.e. Type 2 diabetes. This phenomenon is referred to as “metabolic syndrome” where a confluence of inflammatory conditions occur along with the diabetes. As a result growing evidence appears to show that metabolic syndrome makes the diabetic patient susceptible to degenerative health conditions such as cardiovascular disease stroke and now believed Alzheimer’s disease. As the diabetes epidemic escalates a new sense of urgency has taken hold. Proactive strategies for prevention of the disease are being put in place by international health organizations such as the World Health Organization WHO as well as by the health departments of industrialized and developing countries and even at the local level where food ingredients regulations are being passed. This report charts the changing landscape of the global diabetic population and explores the added health concerns resulting from the metabolic syndrome phenomenon and one of its major risk factors: cardiovascular disease CVD. Furthermore this study evaluates widelyaccepted therapeutic approaches to diabetes that are currently in use while providing an indepth analysis of emerging technologies that will be used to treat diabetes and other inflammatory diseases in the future.
Table of Contents :

1. Overview 8
1.1 Statement of Report 8
1.2 About this Report 8
1.3 Scope of the Report 9
1.4 Methodology 9
1.5 Executive Summary 11

2. Introduction 17
2.1 Demographics of Diabetes 17
2.1.1 Worldwide Diabetes 17
2.1.2 U.S. Diabetes 18
2.2 Economics of Diabetes 22

3. Understanding the Metabolic Conditions Underlying and Associated with Diabetes 28
3.1 PreDiabetes Syndrome 29
3.2 Metabolic Syndrome 29
3.3 Diabetes and Inflammation 32
3.4 Progression of Diabetes 32
3.5 Complications and CoMorbidities in Type 2 Diabetes 33
3.6 Hypoglycemia and Treatment 38
3.7 Risk Factors and Diabetes 39
3.8 Cardiovascular Disease CVD Facts 40

4. Pharmaceutical Industry and the AntiDiabetes Market 51
4.1 The Worldwide Pharmaceutical Industry 51
4.2 Total Diabetes Drug Market Size and Growth 58
4.2.1 Sales of AntiDiabetic Drugs Continue to Rise 61
4.3 Epidemiology/Cost of Treatment 62
4.4 Diabetic Medications Overview 63
4.4.1 Recent Trends in Diabetic Drug Usage 63
4.4.2 Market Influence Factors 67

5. NonInsulin AntiDiabetes Products 69
5.1 AntiDiabetic Drug Therapy Overview 69
5.1.1 Sulfonylureas 72
5.1.2 Meglitinides 73
5.1.3 Biguanides 73
5.1.4 Thiazolidinediones TZDs 74
5.1.5 aGlucosidase Inhibitors 77
5.1.6 Incretin Mimetics/Glucagonlike Peptide GLP1 Analog 77
5.1.7 Amylin Analog 79
5.1.8 DPPIV Inhibitors 79
5.1.9 Other Classes 81
5.1.10 Combination Therapy 81
5.2 Drivers and Trends 82
5.2.1 Market Share of AntiDiabetic Drugs 82
5.2.2 Forecasts for AntiDiabetic Drugs 82
5.2.3 Sales Forecast for the Global Diabetes Market 83
5.3 The Future 84
5.3.1 Practice Patterns 84
5.3.2 New Products in Pipeline 85
5.4 AntiDiabetic Drug Patent Expiry 91
5.5 Regulatory Issues 91

6. Insulin 92
6.1 Insulin Markets 92
6.1.1 Major Players and Market Share 93
6.2 Insulin and Analogs 95
6.2.1 RapidActing Insulin 95
6.2.2 IntermediateActing Insulin 97
6.2.3 LongActing Insulin/Ultra LongActing Insulin 97
6.2.4 Insulin Mixtures 99
6.3 Insulin Analogs 100
6.4 NonInsulins in Development 100
6.5 Pipeline Insulin 101
6.6 NonInvasive Insulin Delivery 101
6.6.1 Inhaled Insulin 101
6.6.1.1 Inhaled Insulin Overview 102
6.6.2 Oral Insulin 104
6.6.3 Transdermal Insulin 106
6.6.4 Oral Spray Insulin 108
6.7 Barriers for NonInjected Insulin 109
6.8 Patient Potential for NonInjected Insulin 109
6.9 Insulin Delivery Devices 109
6.9.1 Lancets and Lancing Devices 110
6.9.2 Insulin Pens 113
6.9.3 Injections Aids 117
6.9.3.1 Automatic Injectors 117
6.9.3.2 Syringe Magnifiers 118
6.9.3.3 Insulin Infusers 118
6.9.4 Insulin Jet Injectors 118
6.9.5 Insulin Pumps 119
6.9.5.1 External Insulin Pumps 119
6.9.5.2 Implantable Insulin Pumps 122
6.9.5.3 Insulin Pump Market Share 123
6.9.5.4 Drivers of Demand for Pumps 128
6.10 Market Forecasts for Insulin Administration Technologies 129

7. Emerging AntiDiabetes Products 130
7.1 Projections for the AntiDiabetes Drug Market 130
7.2 Artificial Pancreas 134
7.3 InsulinProducing Cells 135
7.3.1 Cell Therapy Companies for Diabetes 135
7.4 Transplantation Procedures 137
7.4.1 Pancreatic Transplantation 138
7.4.1.1 Pancreatic Organ Transplantation 138
7.4.1.2 AlloIslet Transplantation 138
7.4.1.3 Transplantation of Encapsulated Pancreatic Cells 139
7.4.1.4 Implantation of Genetically EngineeredCells or Embryonic Stem Cells 139
7.4.2 Current Status 140
7.5 Gastric Bypass Surgery to Treat Type 2 Diabetes 140
7.6 Immune Modulators 141
7.7 AntiObesity Drug Xenical to Prevent or Delay Development of Type 2 Diabetes 141
7.8 Other AntiDiabetic Therapy Drug Candidates 141
7.8.1 Lipid Abnormalities 142
7.8.2 High Blood Pressure 143
7.8.3 Anticoagulants 144
7.9 Drugs Used OffLabel 145
7.9.1 Niacin Derivatives 145
7.9.2 Benfluorex 145
7.9.3 DChiroInositol 145
7.9.4 Warfarin Sodium 145
7.10 Pipeline Diabetic Drug Candidates 146
7.11 Drug Research Overview 149
7.12 Future AntiDiabetic Drugs in LateStage Development 151

8. Diagnosing Diabetes Using In Vitro Laboratory Tests 154
8.1 New Diagnostic Guidelines 154
8.2 Diabetes Tests 155
8.2.1 Fasting Plasma Glucose FPG Test 155
8.2.2 Glucose Tolerance Test 155
8.2.3 Test for Glycosylated Hemoglobin 156
8.2.4 Fructosamine 157
8.3 Glucose Monitoring 157
8.3.1 Overview of Market Segment 160
8.3.2 Competitive Strategies 160
8.3.3 Analyses of the Current Market Conditions Competition and Product Mix 162
8.3.3.1 FirstGeneration Monitors 162
8.3.3.2 SecondGeneration Monitors 162
8.3.3.3 ThirdGeneration SMBG Technologies 164
8.3.3.4 Product Overview 165
8.3.3.4.1 LifeScan 165
8.3.3.4.2 Roche Diagnostics 168
8.3.3.4.3 Bayer Diagnostics 169
8.3.3.4.4 Abbott Diagnostics 172
8.3.3.4.5 Other Players 174
8.3.4 What Are the Advantages of Using a Continuous GlucoseMonitoring Device? 177
8.3.5 Other Monitoring Device Advancements 178
8.3.6 Future of NonInvasive Glucose Technology 179

9. Market Trends Challenges and Strategic Options 182
9.1 Overview 182
9.2 Diabetes Drug Market Trends 182
9.2.1 Overview 182
9.2.2 Emergence of Therapeutics with Improved Administration Characteristics 182
9.2.3 Increasing Prevalence of Obesity 183
9.3 Diabetes Mellitus Market Challenges 185
9.3.1 Overview 185
9.3.2 Diabetic Pain Therapeutics 185
9.3.3 Market Prospects of Inhalable Drugs and Their Ability to Establish Safety Levels 186
9.3.4 Changing Consumer Preference Drives Product Development in Invasive Technology Segment 186
9.3.5 NonInvasive Technology for Revenue Potential 186
9.3.6 Developing Countries Emerging as Key Markets for Diabetes Monitoring Devices 187
9.3.7 ConsumerDriven Marketing CampaignsEssential though Expensive 189
9.3.8 Escalating Expenditure for Ramp;D and Marketing Triggers Consolidation 189
9.3.9 Market Size Predictions 191
9.3.10 Major Competitors 191
9.4 Strategic Options 192
9.4.1 Overview 192
9.4.2 Combined SelfTesting Glucose Monitor with Insulin Delivery 193
9.4.3 Diabetes Drugs in Pipeline 194
9.5 FDA Therapeutic Targets 196
9.5.1 FDA Targets Cardiotoxicity 197
9.5.2 Avandia FDA Warning 197
9.6 Outlook to AntiDiabetes Drugs 197
9.7 Outlook for Cardiovascular Drugs 201

10. Company Profiles 203
10.1 A. Menarini 203
10.2 Abbott Laboratories 203
10.3 Amgen 204
10.4 AstraZeneca 205
10.5 Bayer 206
10.6 BodyMedia 208
10.7 Cybermedical 208
10.8 Debiotech 208
10.9 DexCom 209
10.10 Echo Therapeutics 210
10.11 Elixir Pharmaceuticals 211
10.12 Eksigent 211
10.13 Flamel Technologies 211
10.14 GlaxoSmithKline 212
10.15 GlucoLight 212
10.16 Insulet 212
10.17 iSense Corporation 213
10.18 Isis Pharmaceuticals Inc. 213
10.19 Johnson amp; Johnson 214
10.20 KYORIN 215
10.21 MBiotech 215
10.22 Medtronic 215
10.23 Merck amp; Co. 217
10.24 Merck KGaA 218
10.25 MicroIslet 218
10.26 Mitsubishi Tanabe Pharma Corporation 219
10.27 Nipro Diabetes Systems 219
10.28 Novartis 219
10.29 Novo Nordisk 220
10.30 Novocell 221
10.31 ONO Pharmaceutical 221
10.32 Orexigen Therapeutics 222
10.33 Pfizer 223
10.34 ReNeuron 223
10.35 Roche Diagnostics 224
10.36 SanofiAventis 225
10.37 Sensors for Medicine and Science 226
10.38 Siemens 227
10.39 Smiths Medical 227
10.40 Servier 228
10.41 SOOIL Development 228
10.42 Takeda 228
10.43 TheraFuse 229
10.44 Teco Diagnostics 229
10.45 Transition Therapeutics 229
10.46 U.S. Diagnostics 229
10.47 VeraLight 230
10.48 Vivus 230
10.49 Ypsomed Holding 231

Appendix 1: Contact Information for Companies Profiled 232
Appendix 2: Prescribing Patterns for AntiHyperglycemic Drugs 238
Appendix 3: Detailed List of Insulins Available 239
Appendix 4: The History of Insulin 240
Appendix 5: Diabetes and Obesity Drugs in Development 245
Appendix 6: Pharmaceutical Sampling Practices 253

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